2018 Sino US Health Cooperation Forum - Nobel Suzhou Special Session

• by EVOMT
• 2018-07-26

Professor Michael Rosbash

Yesterday, Professor Michael Rosbash, academician of the National Academy of Sciences and winner of the 2017 Nobel Prize in Physiology or Medicine, came to Suzhou to visit the Suzhou Emergency Center, the Second Affiliated Hospital of the University of Suzhou, and the Guangji Hospital of Suzhou. He also explained the research process of his Nobel Prize achievement "Molecular Mechanism of Biological Circadian Rhythm Regulation" on the spot at the Guangji Hospital of Suzhou, and shared his "success" - keep your curiosity and persevere in doing it

Mayor Li Yaping met with Professor Rosbash and his entourage. Yuan Junying, academician of the National Academy of Sciences and molecular biologist, and Yu Qiang, associate professor of Boston University and head of the Cancer Group of the Chinese Institute of Pharmaceutical Research in the United States, together came to Suzhou and accompanied Professor Rosbash throughout the tour. Tan Weiliang, director of the Municipal Health and Family Planning Commission, and Chen Xiaokang, deputy director, accompanied by Ms. Wu Qiuting, CEO of EVO Medical Services, and hospital leadership

Mayor Li Yaping Meets with Professor Rosbash

Nobel Prize Practical School: "Sleeping late is not scary, as long as there is regularity"

It has long been known that animals, plants, and humans have biological clocks, and this periodic adaptive ability is known as the "circadian rhythm" of living things. However, how this biological clock works internally remains a mystery

In recent years, this mystery has been solved by three American scientists, Jeffrey Hall, Michael Rosbash, and Michael Young. Using Drosophila as the experimental object, three scholars have identified the genes that control the daily biological rhythms of Drosophila, and recorded the process of the proteins controlled by this gene accumulating in cells at night and decreasing during the day "The research achievement of" Molecular Mechanism of Biological Circadian Rhythm Regulation "won the 2017 Nobel Prize in Physiology or Medicine. The Nobel Prize Review Committee stated that" this research explains the internal operating principles of the biological clock and explains how plants, animals, and humans regulate their own biological rhythms. "

Professor Rosbash and his delegation visited the Sleep Center of Guangji Hospital

Research has shown that the biological clock regulates crucial functions such as behavior, hormone levels, sleep, body temperature, and metabolism. Professor Rosbash explained, "When the external environment suddenly doesn't match our biological clock, we feel uncomfortable. If the lifestyle and the internal biological clock are 'aligned', the risk of developing various diseases may increase."

Since Nobel Prize research has solved the mystery of the biological clock, people are wondering how to "get along" with their biological clock. Should they insist on "going to bed early and getting up early is good for their health" or "following their own feelings"? With this question in mind, yesterday's Su Bao reporter specifically consulted Professor Rosbash. In response, Professor Rosbash stated that maintaining a regular biological clock is the most important. He said, "Everyone's habits are different, and there are both early riser and late riser. As long as you maintain your biological rhythm and live according to your daily routine, it is possible to maintain a regular late riser even if you sleep late, which does not necessarily mean that only early riser and early riser are healthy." Immediately, he added, "Of course, those who sleep late need to pay attention. As you continue to work and study the next day, you need to ensure that you have sufficient sleep time to maintain the good spirit of the next day." Sleep can have an impact on aging. "

"My research subject has won five Nobel Prizes"

Yesterday afternoon, the conference room of Guangji Hospital was packed with medical personnel who had come to see the "super tycoon" style. The international "tycoon" Professor Rosbash on the podium was humorous and witty. Even when speaking on such a professional topic, his witty words occasionally caused heartfelt laughter from the audience

Professor Rosbash gave a lecture at Guangji Hospital

For decades, Professor Rosbash has been a companion to fruit flies, both his research object and his good companion. On the night of winning the Nobel Prize, Professor Rosbash's celebration cake was decorated with a huge "fruit fly" and wrote, "It's a big day for the Fruit Fly!". During his presentation, Professor Rosbash also solemnly introduced his little companion, emphasizing that "the sleep of fruit flies is very similar to that of humans, and the effects of sleep posture, drug reactions, increased arousal thresholds, and irregular sleep on aging are all the same as those of humans. Therefore, studying the effects of fruit flies on aging is very important." Understanding the secrets of human sleep has reference value, and fruit flies are also used to simulate and study various human diseases "He also quipped, 'Science has made fruit flies famous. My little friend, fruit flies, has won five Nobel Prizes, and I only won one.'" "Indeed, among the Nobel Prizes awarded, five have been awarded for studying fruit flies.

Listen to Professor Rosbash's lecture

As a rule, Nobel Prize winners will not be notified until 20 minutes before the "opening" of the prize. On the morning of October 2nd last year, Professor Rosbash received the notification of the award "They called me from Stockholm, Sweden, and informed me that it was 5 o'clock in the morning. Oh my God, this time point is not good news for me, who specializes in biological rhythms. They have disrupted my rhythms. Another award-winning companion of mine, who lives in a state at 2 o'clock at night, is also very painful." Speaking of his feelings about winning the Nobel Prize, Professor Rosbash's words were witty and humorous, and closely linked to the theme of his speech, "Three words are inseparable from one's profession," which drew bursts of laughter from the audience

Professor Rosbash and his delegation visited the Second Affiliated Hospital of the Soviet University and took a group photo with representatives of medical staff

Nobel Prize for Success: "Maintain curiosity and persevere in doing it"

In his speech, Professor Rosbash repeatedly emphasized that "I stand on the shoulders of giants", stating that his Nobel Prize was awarded based on the research achievements made by predecessors. His modesty and plainness made the audience admire him immensely

Professor Rosbash said that he did not initially think that he might win a Nobel Prize, but just persevered in completing the work at his disposal "Maintain your curiosity and always be enthusiastic about new fields. Moreover, you should do what interests you, so that you can persevere and persevere, and ultimately you will be happy regardless of the outcome." Professor Rosbash shared his "success study."

Professor Rosbash and his delegation visited the emergency grading and dispatching system of the municipal emergency center

Yu Qiang, an associate professor at Boston University in the United States and head of the oncology group at the Chinese Institute of Pharmaceutical Research, once worked in Professor Rosbash's laboratory. From 1983 to 1989, Yu Qiang studied for a doctor's degree in Professor Rosbash's laboratory, participated in Professor Rosbash's cloning research on the cycle genes of fruit flies, and all the way witnessed Professor Rosbash reaching the pinnacle of the Nobel Prize. Yu Qiang told reporters that Professor Rosbash has always maintained a strong thirst for knowledge in scientific research work, has a wide range of interests, and he also has his own unique "intuition" about the development direction of the scientific field. Professor Rosbash's earliest research field was yeast, and since the 1980s, his research direction has shifted from molecular biology of yeast to molecular biology. The biological behavior of Drosophila melanogaster, Yu Qiang said, "Professor Rosbash recognized that his research object is the most fundamental phenomenon of vitality, and as long as it continues to be valuable, he has persisted for so many years."

"As long as you keep working hard, you will achieve good results; if you have a bit of good luck, such as mine, it will be even better," said Professor Rosbash.